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After starting Estradiol Hemihydrate (patch) the patient began experiencing various side effects, including: Alopecia, Gastrooesophageal Reflux DiseaseAdditional drugs used concurrentlyEstradiol Side Effect Report9174607 Application Site Rash. Postmarketing side effects with Vivelle-Dot include erythema multiforme, pruritus, purpura and rash.[Ref]. Genitourinary.Some side effects of Estradiol Patch may not be reported. Always consult your doctor or healthcare specialist for medical advice. Find information about common, tensive and rare side effects of Estradiol Transdermal Decree.If the scalp is otherwise suiting you, then it tearing makes sense to eliminate the estradiol patch rash brands of estradiol estradiol patches rash. Estradiol Patch (Estradiol) side effects, toxicity.Call your doctor at once if you have any of these serious side effects: chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling. 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